Objectives

To investigate the diagnostic value of serum soluble endorphin (sENG) combined with BISAP score for severe acute pancreatitis (SAP) complicated with septic shock.

Methods

A total of 150 cases of SAP complicated with sepsis were selected and categorized into the group with shock (n=88) and the group without shock (n=42). The general clinical data and laboratory indexes of the two groups were compared. The factors affecting the occurrence of septic shock were explored, and the correlation between serum sENG, BISAP, APACHEII, and SOFA scores was analyzed. The value of sENG and BISAP scores for diagnosis of SAP complicated with sepsis was assessed.

Results

APACHEII score, SOFA score, BISAP score, and serum sENG levels were higher in the group that developed septic shock. Increased BISAP score and elevated serum sENG level were independent risk factors for septic shock in patients with SAP. sENG level was positively correlated with BISAP score, APACHEII, and SOFA score in patients with SAP-complicated sepsis, and BISAP score was also positively correlated with APACHEII and SOFA score. sENG level and BISAP score had a predictive value for patients with SAP complicated with septic shock (AUC=0.723, 0.703), and the combination of the two had the highest value for the diagnosis of SAP complicated with septic shock (AUC=0.838). In addition, the AUC values of the two in predicting poor prognostic outcomes in patients with SAP complicated with sepsis were 0.757 and 0.706, respectively, and the AUC of the combination was 0.796.

Conclusions

Serum sENG and BISAP scores are predictors of septic shock in patients with SAP, and the combination of the two has a more powerful predictive effect and better evaluation significance.

Keywords: severe acute pancreatitis; septic shock; serum soluble ENG; BISAP score; predictive value

• JinBei Yuan  , QiuBao Yang  und Chao Chen  

Aus der Zeitschrift Journal of Laboratory Medicine

https://doi.org/10.1515/labmed-2024-0127